Observation on clinical efficacy of combined therapy of zinc supplement and jinye baidu granule in treating human cytomegalovirus infection.
- Author:
Dan LI
1
;
Liang-zhen WEN
;
Hui Y UAN
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Antibodies, Viral; blood; Antiviral Agents; therapeutic use; Cytomegalovirus; drug effects; Cytomegalovirus Infections; drug therapy; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Immunoglobulin M; blood; Phytotherapy; Zinc; therapeutic use
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(5):449-451
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical efficacy of the combined therapy of zinc supplement and Jinye Baidu granule (JBG) on human cytomegalovirus (HCMV) infection.
METHODSOne hundred and forty patients with positive HCMV-IgM were randomly divided into four groups, with 35 cases in each group, that is, the control group (only medicated with JBG), the high-, moderate- and low-dose zinc combined groups (treated with JBG combined with zinc gluconate tablet at dose of 30 mg, 20 mg, 10 mg every day respectively). The negative conversion rate of HCMV-IgM was observed.
RESULTSInsignificant difference in the negative conversion rate was shown in comparison of the control group with the low dose group (P > 0.05), and in comparison of the high dose with the moderate dose group (P > 0.05); however, the rate was significantly lower in the control group than that in the moderate dose and high dose group (P < 0.05).
CONCLUSIONCombined therapy of zinc supplement and JBG can significantly increase the negative conversion rate of HCMV-IgM. The optimal dosage of zinc gluconate tablet was 20 mg once a day.
