Proapoptotic role of nuclear clusterin in brain.
10.5115/acb.2011.44.3.169
- Author:
Nayoung KIM
1
;
Wan Sung CHOI
Author Information
1. Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea. choiws@gnu.ac.kr
- Publication Type:In Vitro ; Review
- Keywords:
Clusterin;
Apoptosis;
Brain
- MeSH:
Apoptosis;
Brain;
Clusterin;
Glycoproteins;
Protein Isoforms
- From:Anatomy & Cell Biology
2011;44(3):169-175
- CountryRepublic of Korea
- Language:English
-
Abstract:
Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
