Effect of yisui shengxue granule on gene expression in children with beta-thalassemia.
- Author:
Li-min CHAI
1
;
Zhi-kui WU
;
Xin-hua ZHANG
;
Huiguo CAI
Author Information
- Publication Type:Journal Article
- MeSH: Base Sequence; Child; Drugs, Chinese Herbal; therapeutic use; Female; Ferritins; biosynthesis; genetics; Gene Expression Profiling; Humans; Male; Molecular Sequence Data; Phytotherapy; RNA, Messenger; biosynthesis; genetics; beta-Thalassemia; drug therapy; genetics
- From: Chinese Journal of Integrated Traditional and Western Medicine 2005;25(7):591-594
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the mechanism of yisui shengxue granule (YSG) in children with betathalassemia.
METHODSThe changes of hemoglobin (Hb), red blood cells (RBC), reticulocyte (Ret) and fetal hemoglobin (HbF) of 20 children with beta-thalassemia were measured before and after treatment. The effect of YSG on gene expression in myelo-karyocytes in 3 selected children treated effectively by YSG was determined by using DDRT-PCR.
RESULTSThe hematologic parameters were significantly enhanced and the ferritin gene expression declined after treatment respectively, as compared with those before treatment, the difference were significant (P < 0.01 or P < 0.05).
CONCLUSIONYSG could improve the clinical symptoms of children with beta-thalassemia. One of its therapeutic mechanisms may be its action in decreasing ferritin gene expression so as to effectively relieve the accumulation of iron in body.
