Study on mechanism of biminne in treating allergic rhinitis.

Author: Run-hong LIU ¹ ; Xin-min ZHANG ; Su-qin ZHANG
Author Information

1. Institute of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai.
Publication Type:Journal Article
MeSH: Animals; Cell Proliferation; Drugs, Chinese Herbal; therapeutic use; Immunoglobulin E; blood; Lymphocytes; drug effects; immunology; pathology; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Phytotherapy; Random Allocation; Rhinitis, Allergic, Perennial; chemically induced; drug therapy; immunology
From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(7):623-625
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the effect and mechanism of Biminne, a Chinese herbal compound preparation, for treatment of allergic rhinitis (AR).
METHODSAR model of mouse was induced by intraperitoneal injection of ovalbumin (OVA), and the changes in behavior, proliferative activity of splenic lymphocyte, serum levels of total IgE and OVA specific IgE were observed.
RESULTSBiminne showed effects in reducing the frequency of sneezing and nasal rubbing, inhibiting the proliferation of splenic lymphocyte stimulated by phyto-hemagglutinin (PHA) and OVA, and lowering the levels of serum total IgE and OVA specific IgE.
CONCLUSIONBiminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.