Observation on effect of Wuling Capsule in treating poststroke depression.
- Author:
Bin XU
1
;
Wei-yin ZHOU
;
Shui-jing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Antidepressive Agents, Second-Generation; therapeutic use; Capsules; Depression; drug therapy; etiology; psychology; Drug Synergism; Drug Therapy, Combination; Drugs, Chinese Herbal; therapeutic use; Female; Fluoxetine; therapeutic use; Humans; Male; Middle Aged; Phytotherapy; Stroke; complications; Treatment Outcome
- From: Chinese Journal of Integrated Traditional and Western Medicine 2007;27(7):640-642
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of Wuling Capsule (WLC) in treating patients with poststroke depression.
METHODSOne hundred and eight patients with poststroke depression were randomly assigned to three groups, 36 in each. All were treated with routine medicine, but to the WLC group and the FLX group, additional WLC and fluoxetine was given respectively, while to the combined group, both of the two were given. Patients' neurological and cognitive function were estimated by HAMI) scale, MMSE scale, SSS scale and Barthel index (BI) before treatment and at 4 weeks and 12 weeks after treatment.
RESULTSHAMD score and SSS score significantly decreased (P < 0.01) while MMSE score and BI score significantly increased (P <0.05) in all the three groups, but the improvement in decrease of HAMD score and in increase of BI score in the combined group was more significant than those in the other two groups respectively (P<0.05).
CONCLUSIONSWLC is effective in treating patients with poststroke depression and shows synergism with fluoxetine.
