Analysis of NF-κB and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma.
10.22465/kjuo.2016.14.2.63
- Author:
Young LEE
1
;
Jeonghyouk CHOI
;
Dong Gi LEE
;
Koo Han YOO
;
Gyeong Eun MIN
;
Hyung Lae LEE
;
Kyu Yeoun WON
;
Sung Jig LIM
Author Information
1. Department of Urology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea. yookoohan@khu.ac.kr
- Publication Type:Original Article
- Keywords:
NF-κB;
Renal cell carcinoma;
Prognosis;
Immunohistochemistry
- MeSH:
Carcinoma, Renal Cell*;
Humans;
Immunohistochemistry;
Prognosis;
Recurrence;
Transcription Factors
- From:Korean Journal of Urological Oncology
2016;14(2):63-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma (RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival. MATERIALS AND METHODS: Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels. RESULTS: Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage (p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels (p=0.573). CONCLUSIONS: The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival.
