Is the Expression of p53, c-erb-B2 and Ki-67 Influence the Prognosis of the Non-muscle Invasive Urothelial Bladder Cancer?.
10.22465/kjuo.2016.14.2.69
- Author:
Seok Hyun KANG
1
;
Hyun Jin JUNG
;
Eun Kyoung YANG
;
Jae Shin PARK
;
Hoon Kyu OH
;
Duk Yoon KIM
Author Information
1. Department of Urology, School of Medicine, Catholic University of Daegu, Daegu, Korea. dykim@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Urinary bladder neoplasms;
Immunohistochemistry;
Risk assessment
- MeSH:
Decision Making;
Humans;
Immunohistochemistry;
Prognosis*;
Recurrence;
Retrospective Studies;
Risk Assessment;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urological Oncology
2016;14(2):69-75
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The immunohistochemial markers can be used to predict prognosis more accurately for several cancers. In non-muscle invasive urothelial carcinoma, p53, c-erb-B2 and Ki-67 are applicable. We investigated a retrospective analysis of the relation between the markers and clinical prognostic factors of urothelial bladder cancer. MATERIALS AND METHODS: Data from 268 non-muscle invasive urothelial bladder cancer (Ta, T1) patients from one single center were collected. Immunohistochemical evaluation was carried out on 268 (p53, c-erb-B2, Ki-67) cases. Clinical prognostic factors are as follows; number of tumor, tumor invasiveness, tumor grade and recurrence. The sum of all positivity of 3 markers was made as a new factor and evaluation of correlation between this factor and prognostic factors was also done. Statistical analysis was done by chi-squares test and Pearson's correlation test. RESULTS: Through chi-square test, there were significant relations between all markers and tumor invasiveness (p<0.001), tumor grade (p<0.001). Number of tumor is significantly related with Ki-67 (p=0.043). Recurrence is related with c-erb-B2 (p=0.010) and Ki-67 (p=0.043). There was also significant correlations between the sum of the markers and prognostic factors-tumor invasiveness (p<0,001), tumor grade (p<0.001) and recurrence (p=0.007). CONCLUSIONS: In this study, evaluated markers were closely related with clinical prognostic factors and may contribute to decision making on risk-assessment and management strategy for non-muscle invasive urothelial bladder cancer.
