Effects of Ligustrazine on the Contraction of Isolated Rabbit Corpus Cavernosum Strips
- Author:
Hengjun XIAO
1
;
Jihong LIU
;
Chunping YIN
;
Tao WANG
;
Jun CHEN
;
Longchang FAN
;
Zhangqun YE
Author Information
1. the Third Affiliated Hospital of Sun Yat-sen University
- Keywords:
ligustrazine;
corpus cavernosum;
calcium channel;
concentration
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(5):565-567
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the role of ligustrazine on relaxation of the isolated rabbit corpus cavernosum tissue in vitro, the effects of ligustrazine on the corpus cavernosum were observed by using experimental method of smooth muscle strips. Concentration-responses to phenylephine (PE) and KCl were recorded. The results showed that ligustrazine concentration-dependently depressed the contraction response of smooth muscle strips induced by PE. The maximum percentage relaxation of cavernosal strips by ligustrazine was 74.1% ±6.2 % (compared with control: 21.9 % ±5.6 %, P ＜0.01). Ligustrazine concentration-dependently reduced the amplitude of the contraction induced by cumulative doses of PE or KCl, shifted the cumulative concentration response curves of PE and KCl to the right and depressed their maximal responses. It was concluded that ligustrazine could significantly relax the cavernosal muscle contraction induced by PE in vitro. The results suggested that ligustrazine inhibited calcium ion influx.
