The Construction and Investigation of PLGA Artificial Bone by Biomimetic Mineralization
- Author:
Ming ZHAO
1
;
Qixin ZHENG
;
Jinguang WANG
;
Yuntao WANG
;
Jie HAO
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
Poly lactide-co-glycolide;
Mineralization;
artificial bone;
Biomechanics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(6):687-689
- CountryChina
- Language:Chinese
-
Abstract:
To modify the surface property of poly lactide co-glycolide (PLGA) by biomimetic mineralization to construct a new kind of artificial bone. PLGA films and 3 diamensional (3-D) porous scaffolds hydrolyzed in alkaline solution were minerilized in SBF for 14 days. The morphology and composition of the mineral grown on PLGA were analyzed with SEM, FTIR and XRD. The porosity of the scaffolds was detected by using the liquid displacement method. The compressive strength of the scaffolds was detected by using a Shimadzu universal mechanic tester. An obvious mineral coating was detected on the surface of films and scaffolds. The main component of the mineral was carbonated hydroxyapatite (HA) similar to the major mineral component of bone tissues. The porosity of the un-mineralized and mineralized porous scaffolds was (84.86±8.52) % and (79.70±7.70) % respectively. The compressive strength was 0. 784±0. 156 N/mm2 in un-mineralized 3-D porous PLGA and 0. 858±0. 145 N/mm2 in mineralized 3-D porous PLGA. There were no significant differences between the mineralized and un-mineralized scaffolds (P＞0. 05) in porosity and biomechanics. Biomimetic mineralization is a suitable method to construct artificial bone.
