Serum IL-10 Level in Allergic Rhinitis Patients and Its Effect on Serum Total IgE
- Author:
Guanghui LIU
1
;
Rongfei ZHU
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
allergic rhinitis;
IL-10;
total IgE
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(6):724-725
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the level of serum IL-10 in allergic rhinitis patients and the correlation between IL-10 and serum total IgE (TIgE). 50 allergic rhinitis patients and 30 normal subjects were involved in the study. The levels of serum IL-10 and TIgE were measured by enzyme-linked immunosorbent assay (ELISA), and the correlation between serum IL-10 and TIgE was analyzed. In the allergic rhinitis group, the levels of serum IL-10 and TIgE were 8.34±2.48 pg/mL and 142. 6±28.2 KUA/L. In the normal control group, they were 12. 86±2.88 pg/mL and 47.2±12.2 KUA.There were significant differences between the two groups (P＜0.01); and the level of serum TIgE in the patients was negatively correlated with that of IL-10 (r= -0.46, P=0.02). The level of serum IL-10 was significantly decreased in allergic rhinitis patients, which was beneficial to the synthesization of IgE. IL-10 plays an important role in the episode of allergic rhinitis.
