Effect of Homoharringtonine on Corneal Haze after Excimer Laser Photorefractive Keratectomy in Rabbits
- Author:
Mingchang ZHANG
1
;
Li WANG
;
Yong WANG
;
Zhengping DING
;
Caikeng MAI
;
Shaosong NIE
;
Fei CHEN
Author Information
1. 华中科技大学同济医学院附属协和医院
- Keywords:
Homoharringtonine;
PRK;
Haze
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2005;25(6):732-734
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the inhibiting effect of Homoharringtonine HHT) on the corneal haze after excimer laser photorefractive keratectomy (PRK) in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups (A, B and C). The refractive degree of ablation was -10. 0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/mi HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution;Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group. Corneal haze, histopathology, response, ect. were investigated. The corneal haze was sig nificantly less in group A, while the difference between group B and group C was insignificant.Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C. Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.
