Changes of Expression of Stretch-activated Potassium Channel TREK-1 mRNA and Protein in Hypertrophic Myocardium
- Author:
Longxian CHENG
1
;
Fangcheng SU
;
Nsenga RIPEN
;
Hong FAN
;
Kai HUANG
;
Min WANG
;
Hongyu PENG
;
Chunli MEI
;
Fang ZHAO
;
Yuhua LIAO
Author Information
1. 华中科技大学同济医学院附属医院
- Keywords:
hypertrophic myocardium;
stretch-activated potassium channel;
ventricular remodeling;
electrical remodeling
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2006;26(1):31-33
- CountryChina
- Language:Chinese
-
Abstract:
The expression of stretch-activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi quantitative RT PCR and Western blot respectively. At 4th and 8th week after constriction of the abdominal aorta, rats developed significant left ventricular hypertrophy. As compared to sham operated group, stretch activated potassium channel TREK-1 mRNA was strongly expressed and protein was up regulated in operation groups (P＜0.05). It was concluded that the expression of TREK 1 was up regulated in hypertrophic myocardium induced by chronic pressure overload in Wistar rats.
