Vasculogenic mimicry in laryngeal squamous cell carcinoma and its clinicopathological significance.
- Author:
Shiwu WU
;
Lan YU
;
Lei ZHOU
;
Zenong CHENG
;
Danna WANG
- Publication Type:Journal Article
- MeSH:
Carcinoma, Squamous Cell;
blood supply;
Galectin 3;
metabolism;
Head and Neck Neoplasms;
blood supply;
Humans;
Immunohistochemistry;
Laryngeal Neoplasms;
blood supply;
Lymphatic Metastasis;
Neovascularization, Pathologic;
Prognosis
- From:
Journal of Biomedical Engineering
2014;31(4):865-869
- CountryChina
- Language:Chinese
-
Abstract:
The present paper aims to investigate whether or not vasculogenic mimicry (VM) exists in laryngeal squamous cell carcinoma (LSCC), and to elucidate its relationship to microvessel density (MVD), galectin-3 (Gal-3) expression, and clinicopathological factors of patients with LSCC. VM, score of MVD and expression of Gal-3 protein were detected by immunohistochemistry and histochemistry in 83 specimens of LSCC tissue and 20 specimens of normal laryngeal tissue. The positive rate of VM in normal laryngeal tissues was 0%, and was 33.7% in LSCC tissues. There was a significant difference between the two groups (P<0. 01). VM or MVD was significantly related to differentiation, pTNM stages and lymph node metastasis of LSCC (P<0.05), but not to age, gender and tumor site (P>0. 05). And there was a positive correlation between every two of VM, score of MVD, and Gal-3 protein (P< 0. 05). The results suggest that expression of Gal-3 protein may be related to the initiation, angiogenesis and VM formation in LSCC; And VM, angiogenesis and Gal-3 protein may be involved in the development, invasion and metastasis of LSCC.
