Research on progress and prospect of kinase S6K1.
- Author:
Hui ZHANG
;
Junyu LIANG
;
Ji ZHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Diabetes Mellitus, Type 2;
Humans;
Neoplasms;
Obesity;
Ribosomal Protein S6 Kinases, 70-kDa;
metabolism;
Signal Transduction;
TOR Serine-Threonine Kinases;
metabolism
- From:
Journal of Biomedical Engineering
2014;31(4):935-949
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a prevalent metabolic disorder, which seriously affects human health and has become the world's public health problem. Kinase S6K1, an important downstream effector of mammalian target of rapamycin (mTOR), influences specific pathological responses, including obesity, type 2 diabetes and cancer. Presently, S6K1 has become an attractive therapeutic target in the treatment of these disorders. Here, the functions of kinase S6K1, its molecular regulation mechanisms, related pathogenesis of disease and relevant small molecular inhibitors are reviewed. Finally, the prospect of research toward S6K1 is expected as well.
