Association of the polymorphism of synaptobrevins/vesicle-associated membrane proteins 8 gene with coronary heart disease in Chinese Han population.
- Author:
Cheng-cheng DUAN
1
;
Li-xin XU
;
Qian CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Asian Continental Ancestry Group; genetics; Coronary Disease; genetics; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; genetics; Polymorphism, Restriction Fragment Length; genetics; R-SNARE Proteins; genetics
- From: Chinese Journal of Medical Genetics 2010;27(3):329-332
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of synaptobrevins/vesicle-associated membrane proteins 8 (VAMP8) gene rs1010 polymorphism with coronary heart disease (CHD) in Chinese Han population.
METHODSThe allele and genotype frequencies of the VAMP8 gene rs1010 locus in 185 CHD patients and 149 controls were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing.
RESULTSThere was polymorphism of the VAMP8 gene rs1010 locus in the studied population. The distribution of VAMP8 genotypes was in Hardy-Weinberg equilibrium. The frequency of the A allele in the CHD group was significantly higher than that in control (67.3% vs 53.0%, P< 0.05). Multiple logistic regression analysis showed that genotypes AA and AG were independent risk factors of coronary heart disease. The odds ratio (OR) of (AA+AG) genotype versus GG genotype was 1.969,95% CI: 1.032-3.755.
CONCLUSIONThe VAMP8 rs1010 polymorphism was associated with CHD risk in Chinese Han population, the A allele might serve as a genetic risk factor of coronary heart disease.
