Distribution of genetic polymorphisms of serum amyloid protein A1 in healthy Chinese Han and Uighur populations in Xinjiang.

Xiang Xie; Yi-tong MA; Yi-ning Yang; Zhen-yan FU; Xiao-mei LI; Xiang MA; Ding Huang; Fen Liu; Bang-dang Chen; Yang Xiang; Ying Huang

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Distribution of genetic polymorphisms of serum amyloid protein A1 in healthy Chinese Han and Uighur populations in Xinjiang.

Author: Xiang XIE ¹ ; Yi-tong MA ; Yi-ning YANG ; Zhen-yan FU ; Xiao-mei LI ; Xiang MA ; Ding HUANG ; Fen LIU ; Bang-dang CHEN ; Yang XIANG ; Ying HUANG
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1. Department of Coronary Artery Disease, Heart Center of the First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, 830054 PR China.
Publication Type:Journal Article
MeSH: Alleles; Amyloid; genetics; metabolism; Asian Continental Ancestry Group; genetics; Ethnic Groups; genetics; Gene Frequency; ethics; Genotype; Haplotypes; ethics; genetics; Humans; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; genetics; Polymorphism, Single Nucleotide; Protease Nexins; genetics; Serum Amyloid A Protein; genetics
From: Chinese Journal of Medical Genetics 2010;27(4):397-401
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the genetic polymorphisms of rs2229338 and rs12218 loci of serum amyloid protein A1 (SAA1) gene in healthy Chinese Han and Uighur populations of Xinjiang.
METHODSThe genotypes of the SAA1 gene were detected in 316 Uighur and 362 Han healthy individuals by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
RESULTSThe genotype distributions of both populations were in the Hardy-Weinberg equilibrium (both P>0.05). The frequencies of AA, AG and GG genotypes of the rs2229338 locus were 76.6%, 23.4%, and 0 in the Uighurs, and 91.7%, 7.7% and 0.6% in the Hans. There was significant difference in distribution of genotypes between the two populations (P<0.01). The frequencies of CC, CT and TT genotypes of the rs12218 locus were 10.1%, 47.5%, and 42.4% in Uighurs, and 3.3%, 34.3% and 62.4% in Hans. There was also significant difference in distribution of genotypes between the two populations (P<0.01). The A-C and G-T haplotypes were more frequent in the Uighur but the A-T haplotype was more common in the Han population, respectively (both P<0.01).
CONCLUSIONThe mutational frequencies of the tagging SNPs in rs2229338 and rs12218 loci of theSAA1 gene in the Uighurs may be higher than those in Hans.