Research progress in roles of microRNA in polyglutamine diseases.
10.3760/cma.j.issn.1003-9406.2010.04.010
- Author:
Yu-ting SHI
1
;
Hong JIANG
;
Bei-sha TANG
Author Information
1. Department of Neurology, Xiangya Hospital, Neurodegenerative Disorders Research Center, Central South University, Changsha, Hunan, 410008 PR China.
- Publication Type:Journal Article
- MeSH:
Eukaryota;
MicroRNAs;
genetics;
physiology;
Nerve Degeneration;
Neurodegenerative Diseases;
genetics;
Peptides;
genetics;
Trinucleotide Repeat Expansion;
genetics;
Trinucleotide Repeats;
genetics
- From:
Chinese Journal of Medical Genetics
2010;27(4):406-409
- CountryChina
- Language:Chinese
-
Abstract:
Polyglutamine (Poly Q) diseases are a group of neurodegenerative disorders, caused by the formation of PolyQ mutants due to trinucleotide repeats expansion in coding regions of disease-causing genes, which eventually lead to selective neuronal degeneration and death with unclarified pathogenesis. As a new type of genetic regulatory factor, microRNA (miRNA) plays an important role in modulating gene expression in eukaryote. During the recent years, more attention was paid to roles and related mechanism of miRNA involving in neurodegenerative disease, especially PolyQ diseases. This review is focused on research progress in roles of miRNA in the pathogenesis of PolyQ diseases.
