Study on the longevity related mitochondrial genome variation in Bama elderly population in Guangxi province.
- VernacularTitle:广西巴马长寿老人的长寿相关线粒体基因组研究
- Author:
Ze-ping LV
1
;
Chen-guang ZHENG
;
Fang KONG
;
Jie FENG
;
Wen-yu JIANG
;
Cai-you HU
;
Hua LI
;
Yuan LV
;
Gen-fa ZHANG
;
Ze YANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; China; ethnology; DNA, Mitochondrial; analysis; genetics; Genome, Mitochondrial; genetics; Haplotypes; Humans; Longevity; genetics; Mutation; Myanmar; ethnology; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; genetics; Population Groups
- From: Chinese Journal of Medical Genetics 2010;27(4):423-427
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the human mitochondrial DNA (mtDNA) variations associated with longevity in Bama elderly population from Guangxi.
METHODSMitochondrial genome of 20 individuals over 96 years of age was sequenced, and seven target single nucleotide polymorphism (SNPs) were observed by comparing with the standard rCRS sequence, and two were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in a larger population including 208 individuals of 90-113 years old, and 586 unrelated control individuals from Guangxi.
RESULTSThe 4824G frequency of the mtDNA4824A/G locus increased with age both in the long-lived elderly and in controls. And it was significantly higher in controls than that in long-lived population (P<0.05).
CONCLUSIONThe mtDNA4824 A/G is not only an age-related locus, its mutation is also negatively correlated with longevity.
