Association of the ABCG1 gene polymorphism with the susceptibility and severity of coronary atherosclerotic disease.
- VernacularTitle:ABCG1基因两个单核苷酸多态位点与冠状动脉粥样硬化性心脏病易感性及病情严重程度的相关性分析
- Author:
Long MA
1
;
Guang-hui CHENG
;
Hui WANG
;
Li LI
;
Yao-qin GONG
;
Qi-ji LIU
Author Information
- Publication Type:Journal Article
- MeSH: ATP Binding Cassette Transporter, Sub-Family G, Member 1; ATP-Binding Cassette Transporters; genetics; Aged; Asian Continental Ancestry Group; ethnology; genetics; Case-Control Studies; Coronary Artery Disease; ethnology; genetics; pathology; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2010;27(5):506-511
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of the ATP-binding cassette sub-family G member 1 (ABCG1) gene polymorphisms with coronary atherosclerotic disease (CAD) in Chinese Han population.
METHODSA population based case-control association study was carried out in 541 patients with CAD and 649 healthy controls from Chinese Han population. Two single nucleotide polymorphisms (SNPs) of the ABCG1 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Logistic regression was used to compare the genotypic and allelic frequency difference.
RESULTSThe frequency of allele C of rs225374 was significantly higher in the CAD patients than that in the healthy controls (OR=1.186, 95%CI: 1.009-1.394, P=0.039), while the difference was also significant in the male subgroup (OR=1.236, 95%CI: 1.014-1.506, P=0.036). A statistically higher frequency of rs1044317 allele A was found in the CAD patients in comparison to the healthy controls (OR=1.187, 95%CI: 1.009-1.397, P=0.039). In case-only association study, rs225374 showed significant association in the high Gensini score group compared with the low Gensini score group (OR=1.303, 95%CI: 1.024-1.657, P=0.031).
CONCLUSIONThe two SNPs of the ABCG1 gene might be associated with the susceptibility and severity of CAD in Chinese Han population.
