Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population.
- Author:
Hong-mei WANG
1
;
Nan-fang LI
;
Xiao-guang YAO
;
Jing HONG
;
Wen-li LUO
;
Jian-hang CHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Analysis of Variance; China; ethnology; Endosomal Sorting Complexes Required for Transport; genetics; Ethnic Groups; genetics; Female; Gene Frequency; Genotype; Humans; Hyperlipidemias; genetics; Hypertension; genetics; Male; Middle Aged; Nedd4 Ubiquitin Protein Ligases; Obesity; genetics; Polymorphism, Genetic; genetics; Regression Analysis; Ubiquitin-Protein Ligases; genetics
- From: Chinese Journal of Medical Genetics 2010;27(6):668-671
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of the rs4149601 polymorphisms of neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L) and obesity in Xinjiang Kazakh population.
METHODSThe rs4149601 polymorphism of the NEDD4L gene was genotyped in a Xinjiang Kazakh general population including 856 subjects (aged 30 to 60 years, 478 obese and 378 control individuals).
RESULTSThe polymorphism was successfully genotyped in 853 Xinjiang Kazakh subjects. The distribution of the additive model and dominant model (AG+ AA vs. GG) of the rs4149601 polymorphism differed significantly between the case and control in both total and females (all P< 0.05). After adjusting for confounding factors, logistic regression analysis showed that the rs4149601 polymorphism (in dominant model) was significantly associated with obesity (OR= 1.479, 95% CI: 1.103-1.983, P= 0.009) in Kazakh. Covariate variance analysis showed that compared with subjects with AA + AG genotypes, the waist circumference was significantly higher in subjects with GG genotype after adjusting for age, smoking and drinking (P= 0.028).
CONCLUSIONThe genetic variations of the NEDD4L gene may be associated with obesity in Xinjiang Kazakh general population.
