Expression of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia.
- Author:
Yan WANG
1
;
Rui-Rong XU
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250011, Shandong Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Anemia, Aplastic;
genetics;
metabolism;
pathology;
Bone Marrow;
metabolism;
pathology;
Child;
Chronic Disease;
Erythropoietin;
metabolism;
Female;
Granulocyte-Macrophage Colony-Stimulating Factor;
metabolism;
Humans;
Male;
Middle Aged;
RNA, Messenger;
genetics;
Stem Cell Factor;
metabolism;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(5):1100-1102
- CountryChina
- Language:Chinese
-
Abstract:
The objective of this study was to investigate the expressions of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia (CAA) and their significance. The mRNA expressions of EPO, SCF and GM-CSF from 35 CAA patients and 10 healthy individuals were detected by semi-quantitative RT-PCR. The results showed that the levels of EPO, SCF and GM-CSF in CAA patients were obviously lower than those in the healthy individuals (p < 0.01). It is concluded that the immunity disorder mediated by hematopoietic cytokines is one of the pathogenesis in the CAA patients, it provided theoretical basis for guiding clinical treatment.
