Effect of Ultrasound-Guided Radiofrequency Ablation in Incompletely Treated Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization.
10.3348/kjr.2012.13.S1.S104
- Author:
Nam Kyu CHANG
1
;
Sang Soo SHIN
;
Jin Woong KIM
;
Hyung Jun KIM
;
Yong Yeon JEONG
;
Suk Hee HEO
;
Jae Kyu KIM
;
Heoung Keun KANG
Author Information
1. Department of Radiology, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun 519-809, Korea.
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Radiofrequency ablation;
Transcatheter arterial chemoembolization
- MeSH:
Aged;
Aged, 80 and over;
Carcinoma, Hepatocellular/pathology/*therapy/ultrasonography;
Catheter Ablation/*methods;
Chemoembolization, Therapeutic/*methods;
Combined Modality Therapy;
Female;
Humans;
Liver Neoplasms/pathology/*therapy/ultrasonography;
Male;
Middle Aged;
Neoplasm Recurrence, Local;
Postoperative Complications;
Prognosis;
Proportional Hazards Models;
Treatment Outcome;
*Ultrasonography, Interventional
- From:Korean Journal of Radiology
2012;13(Suppl 1):S104-S111
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate the effectiveness of ultrasound-guided radiofrequency (RF) ablation in patients with incompletely treated hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) and to evaluate possible prognostic factors for this therapy. SUBJECTS AND METHODS: Thirty nine patients with incompletely treated single HCC (< or = 5 cm) after TACE were treated with RF ablation. All patients were evaluated for complete tumor ablation rate, local recurrence-free rate, overall survival rate, and complications. Local recurrence-free rate and overall survival rate were calculated using the Kaplan-Meier method. The possible prognostic factors of local recurrence-free rate and survival rate were analyzed using Cox proportional-hazards regression model. RESULTS: The complete tumor ablation rate was 92.3%. Local recurrence-free rates for 1-, 2-, 3-, and 5-years were 81.7%, 63.1%, 53.6%, and 35.7%, respectively. One-, 2-, 3-, and 5-year overall survival rates were 96.9%, 82.9%, 67.8%, and 48.4%, respectively. Among prognostic factors included in the analysis, only tumor diameter (< or = 2 cm versus > 2 cm) was statistically significant in terms of predicting local recurrence. Complications were observed in two patients, one with liver abscess and the other with portal venous thrombosis. CONCLUSION: Ultrasound-guided RF ablation could be effective and safe in treating incompletely treated HCC after TACE. The diameter of HCC was a significant prognostic factor for local recurrence.
