Expression and activity of membrane surface tissue factor in peripheral blood cells of patients with cerebral infarction.
- Author:
Xi-Lian HUANG
1
;
Shen-Xian QIAN
;
Li-Hong CAO
;
Li-Rong LIU
;
Jun-Feng TAN
;
Peng-Fei SHI
;
Da-Quan GAO
;
Ya-Ping XIE
Author Information
1. Department of Hemotology, Hangzhou First People Hospital, Hangzhou 31006, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Blood Cells;
metabolism;
Case-Control Studies;
Cerebral Infarction;
blood;
metabolism;
Erythrocyte Membrane;
metabolism;
Female;
Flow Cytometry;
Humans;
Male;
Middle Aged;
Monocytes;
metabolism;
Thromboplastin;
metabolism
- From:
Journal of Experimental Hematology
2008;16(6):1376-1378
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the expression and activity of membrane surface tissue factor (TF) of monocytes and platelets in peripheral blood cells from patients with cerebral infarction and their clinical significance. The TF expressions in monocytes and platelets from 25 patients with cerebral infarction were detected by flow cytometry, the TF activity was detected by chromogenic reaction method, and compared with 24 normal people used as control. The results showed that the TF expressions of monocytes and platelets in peripheral blood cells from patients with cerebral infarction were significantly higher than that in normal controls (p<0.01), and TF activity was also higher in patients than that in controls (p<0.01). In conclusion, the expression and activity of membrane surface in patients with cerebral infarction were enhanced, the hematocyte-derived tissue factor as a trigger in coagulation pathway is involved in pathological thrombosis in patients with cerebral infarction.
