Effect of trimitazidine on insulin resistance in patients with coronary heart disease.
- Author:
Jian-sheng CAI
1
;
Zhi-jian PENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Blood Glucose; metabolism; Cohort Studies; Coronary Artery Disease; blood; drug therapy; Female; Humans; Insulin; blood; Insulin Resistance; Male; Middle Aged; Treatment Outcome; Trimetazidine; therapeutic use; Vasodilator Agents; therapeutic use
- From: Journal of Southern Medical University 2006;26(2):222-226
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of trimetazidine on insulin resistance in patients with coronary heart disease (CHD).
METHODSA cohort of 119 CHD patients were randomly divided into groups A and B receiving the same basic therapy, and the patients in group B were given additional trimetazidine 20 mg 3 times daily for 8 weeks. Before and after treatment, the changes in blood glucose, insulin levels and insulin sensitivity index were evaluated.
RESULTSThe patients in group B showed better outcome than those in group A. After 8 weeks' trimetazidine therapy, the fasting insulin and that at 2 h after oral glucose were decreased (P<0.01), and the insulin sensitivity index was improved (P<0.01).
CONCLUSIONTrimetazidine may produce obvious therapeutic effect on insulin resistance in CHD patients.
