The assessment of symptomatic burden among Ph/BCR- ABL negative myeloproliferative neoplasm patients.
- Author:
Junqing XU
1
;
Zefeng XU
;
Jingya WANG
;
Bing LI
;
Xiujuan SUN
;
Tiejun QIN
;
Yue ZHANG
;
Hongli ZHANG
;
Liwei FANG
;
Lijuan PAN
;
Naibo HU
;
Shiqiang QU
;
Zhijian XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; diagnosis; physiopathology; Polycythemia Vera; complications; Primary Myelofibrosis; complications; Thrombocythemia, Essential; complications
- From: Chinese Journal of Hematology 2016;37(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the value of myeloproliferative neoplasms Symptom Assessment Form total symptom score (MPN-SAF-TSS)in assessing constitutional symptoms among Ph/BCR- ABL negative myeloproliferative neoplasm (MPN)patients.
METHODSA cohort of 628 MPN patients were evaluated by MPN- SAF- TSS.
RESULTSFatigue was the most common symptom (76.0%, 76.2%vs 89.9%)and the highest average severity of all the symptoms (3.46±2.97, 3.47±2.99vs 4.74±3.04 scores)among polycythemia vera (PV), essential thrombocythemia (ET)and primary myelofibrosis (PMF)patients. Using the MPN- SAF- TSS analysis, PMF patients showed highest burden of symptoms (28.9 ± 19.1), followed by PV patients (19.2 ± 16.8), and finally ET patients (17.1 ± 15.3). Instinct differences were observed between PMF and PV patients (χ(2)=6.371,P=0.021), PMF and ET patients (χ(2)= 14.020,P<0.001). No significant difference was found between PV and ET patients (χ(2)=2.281,P=0.191).
CONCLUSIONMPN- SAF- TSS was effective in evaluating the symptomatic burden among Ph/BCRABL negative MPN patients and could be used for serial assessment in this clinical setting.
