The usage of Mayo staging system in Chinese patients with primary light chain amyloidosis.
- Author:
Xufei HUANG
1
;
Jun FENG
;
Congli ZHANG
;
Kaini SHEN
;
Chunlan ZHANG
;
Jian SUN
;
Zhuang TIAN
;
Xinxin CAO
;
Lu ZHANG
;
Daobin ZHOU
;
Jian LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Amyloidosis; diagnosis; Female; Humans; Immunoglobulin Light-chain Amyloidosis; Male; Middle Aged; Prognosis; Retrospective Studies; Young Adult
- From: Chinese Journal of Hematology 2016;37(4):278-282
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the usage of Mayo staging system in Chinese patients with primary light chain (LC) amyloidosis.
METHODClinical data, treatment and outcome of 162 primary LC amyloidosis patients with Mayo Clinic staging in Peking Union Medical College Hospital from January 2009 to June 2015 were retrospectively analyzed.
RESULTSThe median age of 162 patients with Mayo Clinic 2004 stage was 57 (20-81) y, of them 62.3% were male. The number of patients with stage I to III were 44 (27.2%), 69 (42.6%), and 49 (30.2%), respectively. The median overall survival was not reached, 23 months and 12 months in patients with Mayo Clinic 2004 stage I, II, and III, respectively (P<0.001). Among 128 patients with Mayo Clinic 2012 stage, 48 patients (37.5%), 32 patients (25.0%), 32 patients (25.0%) and 16 patients (12.5%) were staged as Mayo Clinic 2012 stage 1 to 4, and the median OS was not reached, not reached, 13 months and 3 months, respectively (P<0.001).
CONCLUSIONMayo Clinic staging systems had important prognostic value in patients with primary LC amyloidosis.
