A case-control study on congenital heart diseases with methylenetetrahydrofolate reductase gene, cystathionine beta-synthase gene, and environmental factors.
- Author:
Xiao-qiang QIU
1
;
Qiu-an ZHONG
;
Xiao-yun ZENG
;
Yong-hong LI
;
Shao-fa NIE
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Child, Preschool; Cystathionine beta-Synthase; genetics; Depression; Environmental Exposure; Female; Genetic Predisposition to Disease; Genotype; Heart Diseases; congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); genetics; Odds Ratio; Pesticides; toxicity; Pregnancy; Pregnancy Complications; Risk Factors
- From:Chinese Journal of Epidemiology 2006;27(3):260-263
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore congenital heart diseases (CHD) in their offsprings in association with parental methylenetetrahydrofolate reductase (MTHFR) gene C677T, cystathionine beta-synthase (CBS) gene T833C, and environmental factors.
METHODSA 1:1 case-control study was carried out to investigate 115 pairs of case and controlled children and their parents, and the parents' MTHFR gene 677 C-->T mutation and CBS gene 833 T-->C mutation were also identified. The possible risk factors were analysed by simple and multiple factors logistic regression methods.
RESULTSResults revealed that 5 factors were related to the occurrence of CHD in the offsprings: maternal exposures to pesticides in the early stage of pregnancy (OR = 8.62), suffering from diseases during pregnancy (OR = 2.069), catching cold in the early stage of pregnancy (OR = 4.125), under depressed or nervous condition during pregnancy (OR = 4.653), maternal MTHFR 677TT genotype (OR = 3.872).
CONCLUSIONThese results suggested that maternal MTHFR 677TT genotype was one of the risks to the occurrence of CHD in offspring but parents' CBS gene 833 T-->C mutation did not get involved in CHD. In addition, the occurrence of CHD was related to maternal exposures to pesticides, catching a cold, suffering from diseases, depressed or under nervous condition in the early stage of pregnancy or during pregnancy.
