A molecular epidemiological study on human plague fulminant epidemic in Qinghai, 2004.
- Author:
Zhi-zhen QI
1
;
Er-hei DAI
;
Dong-sheng ZHOU
;
Yong-hai YANG
;
Shou-hong YU
;
Rui-xia DAI
;
Hai-hong ZHAO
;
Min LI
;
Rui-fu YANG
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Disease Outbreaks; Genotype; Humans; Molecular Epidemiology; Plague; epidemiology; Yersinia pestis; genetics; isolation & purification
- From: Chinese Journal of Epidemiology 2006;27(4):316-318
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the epidemiology of genotyping Yersinia pestis isolated in the fulminant epidemics of human plague in Qinghai province in 2004.
METHODSPrimer pairs targeting the twenty-three different identified regions (DFRs) were designed to detect the presence or deletion of each DFR in 13 strains of Yersinia pestis isolated from the fulminant epidemic of human plague in Qinghai province in 2004.
RESULTSThere were 4 genomovars, i.e. Genomovar 8, 10, 15 and 16 in the 13 strains of Yersinia pestis identified. The genomovar of all the strains of Yersinia pestis isolated from Nangqian county was Genomovar 10. Among the two strains of Yersinia pestis isolated from Wulan county, the genomovar of one strain was Genomovar 8 and the other was Genomovar 10. The genomovars of all the strains of Yersinia pestis isolated from Qilian, Qumalai and Chengduo county belonged to Genomovar 16.
CONCLUSIONIt was demonstrated that the genotyping of Yersinia pestis appeared to be a powerful tool for investigating human plague epidemics.
