Study on the genotyping and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau.
- Author:
Min LI
1
;
Er-hei DAI
;
Rui-xia DAI
;
Dong-sheng ZHOU
;
Xiao-yan YANG
;
Bai-zhong CUI
;
Li-xia JIN
;
Hai-hong ZHAO
;
Cun-xiang LI
;
Mei-ying QI
;
Dun-zhu Ci REN
;
Xiang DAI
;
Yong-jiao TANG
;
Rui-fu YANG
Author Information
- Publication Type:Journal Article
- MeSH: Biological Evolution; China; Geography; Humans; Plague; transmission; Yersinia pestis; genetics
- From: Chinese Journal of Epidemiology 2006;27(5):412-415
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the distribution of genomovars and microevolution of Yersinia pestis in the Qinghai-Tibet Plateau.
METHODSPrimer pairs targeting the twenty-two different regions(DFRs) were designed for detecting the presence or deletion of each DFR in 297 strains isolated from the Qinghai-Tibet Plateau.
RESULTS9 genomovars, i. e. Genomovar 1, 5, 6, 7, 8, 10, 11, new type and Ype-ancestor were identified in the Marmota himalayana plague focus of the Qinghai-Tibet Plateau. Among these genomovars, genomovar 5,8 and 10 were dominant types. The total rate of the three genomovars was 80.6% (204/253) and the genomovars in different regions were different. All of 44 strains of Y. pestis in the Microtus fuscus plague focus of the Qinghai-Tibet Plateau belonged to genomovar 14.
CONCLUSIONThe distribution of genomovars of Y. pestis in the Qinghai-Tibet plateau had remarkable characteristics geographically. Based on the distribution of genomovars of Y. pestis, the routes of transmission and microevolution of Y. pestis were proposed.
