Association study between single nucleotide polymorphism in AOAH gene and chronic rhinosinusitis in a Chinese population
10.3760/cma.j.issn.1673-0860.2014.08.010
- VernacularTitle:酰基羧酸水解酶基因多态性与中国人群慢性鼻-鼻窦炎的相关性研究
- Author:
Yanming ZHAO
1
;
Yuan ZHANG
;
Xiaohui CUI
;
Yu RUAN
;
Luo ZHANG
Author Information
1. 100730,首都医科大学附属北京同仁医院耳鼻咽喉头颈外科
- Keywords:
Sinusitis;
Polymorphism,single nucleotide;
Carboxylic ester hydrolases
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2014;49(8):668-674
- CountryChina
- Language:Chinese
-
Abstract:
Objective To replicate the polymorphisms in risk genes of chronic rhinosinusitis in a Chinese Han population.Methods Enrolled in this study were CRS patients with nasal polyps (n =306,CRSwNP),CRS patients without nasal polyps (n =332,CRSsNP),and controls (n =315) in a Chinese population.All the patients were recruited from clinic of the department of Otorhinolaryngology of Beijing Tongren Hospital between 2008 February and 2009 July.A total of 10 single nucleotide polymorphisms (SNPs) selected from previous identified SNPs associated with CRS in Canadian population were individually genotyped.Allele and genotype frequencies were calculated by frequency counting,the chi-square test or exact method were applied to analyze the results.Final results were corrected by Bonferroni multiple correction.SPSS 13.0 software was used for statistical analysis.Results One SNP in AOAH gene (rs4504543,P =1.95 × 10-5,OR =0.559 0) was identified to be significantly associated with whole CRS cohort.After subgroup analysis for the presence of nasal polyps (CRSwNP and CRSsNP),the same SNP in AOAH (rs4504543,P =3.47 × 10-12,OR =0.284 8) was also found to be significantly associated with CRSsNP cohorts.Conclusions AOAH was significantly associated with CRS and its polymorphisms might play a role in the susceptibility to develop CRS in Chinese population.
