The nucleus origin of acoustically evoked short latency negative response in guinea pigs.
- Author:
Shaohua ZHANG
1
;
Wenqin HUANG
1
;
Chenxi LIN
1
;
Jin CHEN
1
;
Dongxiao NONG
2
;
Anzhou TANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Acoustics; Animals; Cochlear Nucleus; Evoked Potentials, Auditory, Brain Stem; Guinea Pigs; Reaction Time; Saccule and Utricle; Vestibular Nuclei
- From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2014;49(10):848-853
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThis study established a model of acoustically evoked short latency negative response (ASNR) in guinea pigs. Stereotaxic coordinate guided electrolytic lesion was applied to animal brainstem nuclei, the vestibular nucleus and the cochlear nucleus, to define the neural origin of ASNR.
METHODSTwenty four guinea pigs with normal hearing were randomly divided into the control group (8 subjects, 16 ears) and the deafened group (16 subjects, 32 ears). Each animal experienced the auditory brainstem response (ABR) test. According to the presence of ASNR, the deafened group was further divided into ASNR group and non-ASNR group. Electrolytic lesion was conducted to the vestibular nucleus and cochlear nucleus respectively, followed by ABR test. The lesion structures were verified by brainstem slice and microscope.
RESULTSIn deafened group, the ASNR was elicited in 10 ears (31.3%). The ASNR was eliminated due to the electrolytic destruction to the vestibular nucleus, but it remained unchanged after the same procedure to the cochlear nucleus.
CONCLUSIONIt is clear that the ASNR is originated from the vestibular nucleus, but not the cochlear nucleus.
