Expressions of metastatic tumor antigen 1 and hypoxia-inducible-factor l alpha in lung cancer and their clinical significance.
- Author:
Xiao-xia ZHU
1
;
Yu GUO
;
Long-hua CHEN
;
Yan-qing DING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylases; metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; metabolism; Immunohistochemistry; Lung Neoplasms; genetics; metabolism; pathology; Male; Middle Aged; Repressor Proteins; metabolism
- From: Journal of Southern Medical University 2009;29(4):642-644
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation of the expressions of metastatic tumor antigen 1 (MTA1) and hypoxia-inducible-factor l alpha (HIF-1alpha) to the clinical features of lung cancer.
METHODSThe expressions of MTA1 and HIF-1alpha proteins in 59 lung cancer patients were detected by immunohistochemistry.
RESULTSPositive staining of MTA1 and HIF-1alpha was found in 54.24% and 50.85% of the patients, respectively. MTA1 expression was not found to correlated to any of the clinical parameters. HIF-1alpha expression was significantly lower in poorly differentiated than in moderately and well differentiated lung cancer (P<0.05), and a positive association between the expressions of MTA1 and HIF-17alpha were noted (P<0.05).
CONCLUSIONMTA1 and HIF-1alpha overexpression occurs in lung cancer possibly as an important factor of lung carcinogenesis. MTA1 may promote lung carcinogenesis by enhancing HIF-1alpha protein activity.
