Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance.
- Author:
Gui-qin SUN
1
,
2
;
Mei ZHONG
;
Yan-qing DING
;
Gui-dong SU
;
Tian-rong SONG
;
Ai-lan YIN
Author Information
- Publication Type:Journal Article
- MeSH: Cystadenocarcinoma; genetics; pathology; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Staging; Ovarian Neoplasms; genetics; pathology; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Trans-Activators; genetics
- From: Journal of Southern Medical University 2009;29(4):685-688
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the correlation of ZNF217 expression to the carcinogenesis and progression of human ovarian cancer.
METHODSImmunohistochemistry and real-time RT-PCR were used to detect ZNF217 expression in human ovarian cystadenocarcinoma, ovarian cystadenoma and normal ovary tissues.
RESULTSThe expression levels of ZNF217 protein and mRNA in ovarian cystadenocarcinoma was significantly higher than those in matched ovarian cystadenoma and normal tissues (P<0.05). No significant difference was found in the expression between ovarian cystadenoma and normal ovarian tissues (P>0.05). The mRNA expression in the specimens was consistent with the protein expression of ZNF217 (P<0.05).
CONCLUSIONZNF217 gene expression is closely correlated to the occurrence and clinical stages of ovarian carcinomas, suggesting that ZNF217 can be an important candidate gene responsible for the occurrence and progression of ovarian carcinomas.
