Effect of the drug-resistant attenuated Bacillus proteus on CD80 and CD86 protein expression in peripheral blood dendritic cells of hepatitis B patients.
- Author:
Peng WANG
1
;
Si-yun SHU
;
Yan-qun HU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; B7-1 Antigen; metabolism; B7-2 Antigen; metabolism; Bacillus; drug effects; immunology; Case-Control Studies; Child; Dendritic Cells; immunology; metabolism; Drug Resistance, Bacterial; Female; Gene Expression Regulation; immunology; Hepatitis B; immunology; metabolism; Humans; Male; Middle Aged; Vaccines, Attenuated; immunology; Young Adult
- From: Journal of Southern Medical University 2009;29(4):801-803
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of the drug-resistant attenuated Bacillus proteus on the protein expression of CD80 and CD86 in peripheral blood dendritic cells (DCs) of hepatitis B patients.
METHODPeripheral blood monocytes were isolated from HBV-infected patients and the DCs were separated and induced to differentiate in vitro. The expression of CD80 and CD86 proteins on cultured DCs were examined using flow cytometry.
RESULTSThe expression rate of CD80 and CD86 of chronic hepatitis B patients increased significantly (P=0.000), while the positive expression rate of CD80 and CD86 showed no obvious variation in healthy individuals (P=0.185 and P=0.118, respectively).
CONCLUSIONSBacillus proteus can significantly increase CD80- and CD86-positive cell percentage in peripheral blood DCs of HBV-infected patients, but has no such an effect in healthy individuals.
