The influence of c-Myc, Ki-67, MMP-2 and VEGF expression on the prognosis of hepatocellular carcinoma patients with tumor resection.
- Author:
Jun CUI
1
;
Bao-wei DONG
;
Ping LIANG
;
Xiao-ling YU
;
De-jiang YU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; metabolism; surgery; Female; Humans; Ki-67 Antigen; biosynthesis; genetics; Liver Neoplasms; metabolism; surgery; Male; Matrix Metalloproteinase 2; biosynthesis; genetics; Middle Aged; Postoperative Period; Prognosis; Proto-Oncogene Proteins c-myc; biosynthesis; genetics; Retrospective Studies; Vascular Endothelial Growth Factor A; biosynthesis; genetics
- From: Chinese Journal of Hepatology 2004;12(11):660-662
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo explore the effect of c-Myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinoma (HCC) patients who had tumor resection.
METHODSPrimary HCC patients who underwent tumor resection were retrospectively analyzed. The maximum size of their mononodular tumors was less than 5 cm, and no intrahepatic arterial chemotherapy was performed before the resections. They were followed up after resection and the time of recurrence was recorded. They were divided into 2 groups: group A (15 cases): tumor recurred within 1 year after tumor resection; group B (15 cases): with tumor recurrence after 2 years or without it. Paraffin sections of the tumors were remade from their old blocks. Immunohistochemistry stainings were performed with c-Myc, Ki-67, MMP-2 and VEGF monoclonal antibodies. Staining intensity of the tumor and paracancer tissues was quantitatively analyzed.
RESULTSc-Myc, Ki-67, MMP-2 and VEGF expressing intensities in cancer tissues in group A were higher than those in group B, and their expressed intensities in paracancer tissue in group A and B were not significantly different.
CONCLUSIONThe expressions of c-Myc, Ki-67, MMP-2 and VEGF in cancer tissues of the patients are related to the recurrence of their HCC after tumor resection.
