The relationship of serum metalloproteinase with the severity of liver fibrosis and inflammation.
- Author:
Shan-shan YIN
1
;
Xin-min LI
;
Bao-en WANG
;
Tai-ling WANG
;
Ji-dong JIA
;
Lin-xue QIAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Biomarkers; blood; Female; Hepatitis B, Chronic; blood; complications; Humans; Liver Cirrhosis; blood; virology; Male; Matrix Metalloproteinase 1; blood; Matrix Metalloproteinase 2; blood; Middle Aged; Tissue Inhibitor of Metalloproteinase-1; blood
- From: Chinese Journal of Hepatology 2004;12(11):666-668
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of serum metalloproteinase with the severity of liver fibrosis and inflammation.
METHODSA total of 88 patients with HBV-related liver fibrosis and early cirrhosis were enrolled from six hospitals. Serum fibrosis markers including hyaluronic acid (HA), IV collagen (IV-C), aminoterminal propeptide of type III procollagen (PIIIP), laminin (LN), matrix metalloproteinases (MMP) 1, 2, 9 and tissue inhibitors of metalloproteinase (TIMP) 1, 2 levels were determined. Liver biopsies were assessed according to a modified Scheuer and Chevallier's scoring system.
RESULTSSerum TIMP1 (r=0.540) and MMP2 (r=0.314) were correlated positively with the degree of hepatic fibrosis, whereas serum MMP1 (r=-0.495) was correlated negatively. By receiver operating curve analysis (ROC), the sensitivity to distinguish the fibrosis stage 2 from stage 1 was 90.5% and the specificity was 52.0% if the cut-off value of MMP1 was 13.96 ng/ml, and the sensitivity was 91.6% and the specificity was 64.0% if the cut-off value of TIMP1 was 76.84 ng/ml. The sensitivity to distinguish cirrhosis (stage 4) from fibrosis (stage 3) was 70.7% and specificity was 80.9% if the cut-off value of MMP1 was 6.86 ng/ml, and the sensitivity was 60.5% and the specificity was 92.3% if the cut-off value of TIMP1 was 210.04 ng/ml.
CONCLUSIONSerum TIMP1, MMP1, MMP2 levels and TIMP1/MMP1 ratio could be used as serum fibrosis markers.