Relationship of endothelin-1 (ET-1) TaqI and tumor necrosis factor (TNF) a gene polymorphism with portal hypertension in liver cirrhosis.
- Author:
Yuan-qiao CHENG
1
;
Wen-qi WANG
;
Ju-sheng LIN
;
Ping XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Endothelin-1; genetics; Female; Gene Frequency; Hepatitis B, Chronic; complications; genetics; Humans; Hypertension, Portal; etiology; genetics; Liver Cirrhosis; complications; genetics; virology; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic; genetics; Taq Polymerase; genetics; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Hepatology 2004;12(11):669-672
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study whether liver cirrhosis and portal hypertension are associated with ET-1 TaqI polymorphism and TNFa promoter-308G to A polymorphism.
METHODSA case control study of 106 patients with liver cirrhosis following HBV C infection was performed in comparison with 108 controls by PCR-RFLP.
RESULTSThe frequency of C allele and CC+TC genotype in TaqI polymorphism of ET-1 gene in the portal hypertension group (LC+) was significantly higher than that in the healthy controls, and the frequency of TNF2/1 genotype in TNFa promoter -308 G to A polymorphism in LC+ group was significantly higher than that in the control group. The results by stratification analysis showed that TCF2 genotype frequency was higher in the LC+ group than in the control group. ET-1 TaqI polymorphism and TNFa polymorphism were risk factors for the occurrence of portal hypertension by Logistic regression analysis.
CONCLUSIONET-1 TaqI polymorphism and TNFa polymorphism are associated with portal hypertension, and are new risk factors for the occurrence of portal hypertension. TCF2 genotype may be a susceptible gene of portal hypertension.
