Clinical features of 35 cases of autoimmune hepatitis-primary biliary cirrhosis overlap syndrome.
- Author:
Zhen ZENG
1
;
Yu-Kun HAN
;
Xiao-Feng ZHANG
;
Hua GENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Autoantibodies; blood; Cholagogues and Choleretics; therapeutic use; Female; Hepatitis, Autoimmune; complications; diagnosis; drug therapy; Humans; Immunoglobulin G; blood; Liver Cirrhosis, Biliary; complications; diagnosis; drug therapy; Male; Middle Aged; Retrospective Studies; Ursodeoxycholic Acid; therapeutic use
- From: Chinese Journal of Hepatology 2005;13(1):3-5
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo realize the clinical features of autoimmune hepatitis-primary biliary cirrhosis (AIH+PBC) overlap syndrome.
METHODSWe analyzed and compared the biochemistry, autoimmune antibodies, and liver biopsy results of 129 autoimmune hepatic disease cases retrospectively, using the international criteria to see which could be diagnosed as AIH/PBC overlap syndrome.
RESULTSOur 35 AIH+PBC overlap syndrome patients were mainly women, with a sex ratio of 1 female: 10 male, and a median age of 50.79+/-11.27 (20 to 70 years old). They had AIH characteristics such as flare of ALT, AST and elevated immunoglobulin G (IgG), gamma-immunoglobulin. There were also antinuclear antibodies (74.3%); moderate or severe periportal or periseptal lymphocytic infiltration, piecemeal necrosis, and florid bile duct lesions, high serum levels of ALP, presence of mitochondrial antibodies (68.6%) and M2 antibodies (45.7%), and features of PBC.
CONCLUSIONSAIH+PBC overlap syndrome is not rare. It should be diagnosed in time and to find effective treatments for it.
