The value of antimitochondrial antibody and its subtypes in the diagnosis of primary biliary cirrhosis.
- Author:
Ding-Kang YAO
1
;
Wei-Fen XIE
;
Wei-Zhong CHEN
;
Hai-Ying LIU
;
Xiao-Qing TU
;
Li-Ying FAN
Author Information
- Publication Type:Journal Article
- MeSH: Autoantibodies; blood; classification; Female; Humans; Liver Cirrhosis, Biliary; diagnosis; immunology; Male; Mitochondria, Liver; immunology
- From: Chinese Journal of Hepatology 2005;13(1):9-11
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEA study on the value of antimitochondrial antibody (AMA) and its subtypes anti-M2, anti-M4, and anti-M9 in diagnosing primary biliary cirrhosis (PBC).
METHODSAntimitochondrial antibody was detected by indirect immunofluorescence and anti-M2, anti-M4 and anti-M9 by Western blotting. AMA and anti-M2 of 78 PBC patients, of 35 non-PBC hepato-biliary disease patients and 20 healthy controls were studied and anti-M2, anti-M4 and anti-M9 were studied in 30 of the 78 PBC patients.
RESULTS96.2% (75/78) of PBC patients were AMA positive and 94.9% (74/78) of PBC patients were anti-M2 positive. Only three among the 35 non-PBC patients were positive for AMA (one with very low titre). None of the 35 non-PBC patients was anti-M2 positive. AMA and anti-M2 were negative in all the healthy controls. Among the 30 anti-M2 positive patients, 16 patients were anti-M4 positive (16/30, 53.3%) and 4 patients were anti-M9 positive (4/30, 13.3%).
CONCLUSIONAMA and its subtypes (special anti-M2) are important sero-immunological markers for the diagnosis of PBC.