Regulatory effects of Bmi-1 gene on self-renewal of hematopoietic stem cells--review.
- Author:
Hui GONG
1
;
Yi-Cheng ZHANG
;
Wen-Li LIU
Author Information
1. Department of Hematology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
physiology;
Cell Division;
physiology;
Hematopoietic Stem Cells;
cytology;
physiology;
Humans;
Nuclear Proteins;
genetics;
physiology;
Polycomb Repressive Complex 1;
Proto-Oncogene Proteins;
genetics;
physiology;
Repressor Proteins;
genetics;
physiology
- From:
Journal of Experimental Hematology
2006;14(2):413-415
- CountryChina
- Language:Chinese
-
Abstract:
Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. The Bmi-1 gene is a putative oncogene belonging to the Polycomb group family. Recent studies have shown that the Polycomb-group gene Bmi-1 is indispensable for regulation of self-renewal of normal and leukemic stem cells. The research progress on structure and function of Bmi-1 gene, and its role in self-renewal of hematopoietic stem cells was reviewed.
