Expression and role of beta-catenin in acute leukemia bone marrow cells.
- Author:
Sheng-Mei CHEN
1
;
Hui SUN
;
Yan-Fang LIU
;
Qiu-Tang ZHANG
Author Information
1. Department of Hematology, The First Affiliated Hospital, Zhengzhou University, Zhenzhou 450052, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Bone Marrow Cells;
metabolism;
Flow Cytometry;
Humans;
Immunohistochemistry;
Ki-67 Antigen;
analysis;
Leukemia;
metabolism;
pathology;
beta Catenin;
analysis
- From:
Journal of Experimental Hematology
2006;14(3):460-463
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to explore the expression of beta-catenin in acute leukemia bone marrow cells and its role in the development of acute leukemia. The expression of beta-catenin of bone marrow cells was detected by immunocytochemistry and flow cytometry in 20 cases of newly diagnosed acute leukemia. Meanwhile the expression of the proliferating index Ki-67 was detected by immunocytochemistry. The results showed that the expression of beta-catenin and Ki-67 in acute leukemia bone marrow cells was significantly higher than those in control group (P < 0.05). The migration of beta-catenin from cytoplasm to nuclear was observed in acute leukemia bone marrow cells. There was a positive correlation between the expressions of beta-catenin and Ki-67 in all the cases and the Pearson correlation coefficient was 0.845. In conclusion, the expression of beta-catenin was significantly high in acute leukemia bone marrow cells and showed a positive correlation with the cell proliferation. It suggests that beta-catenin may be involved in the development of acute leukemia through promoting the excessive proliferation of cells.
