Role of B-cell-activating-factor in immune regulation--review.
- Author:
Jian-Fang DU
1
;
Jia-Xi WANG
;
Dong-Gang XU
Author Information
1. Department of Molecular Genetics, Institue of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850 China.
- Publication Type:Journal Article
- MeSH:
B-Cell Activating Factor;
immunology;
B-Cell Activation Factor Receptor;
immunology;
B-Cell Maturation Antigen;
immunology;
B-Lymphocytes;
immunology;
Humans;
Immunity;
Transmembrane Activator and CAML Interactor Protein;
immunology
- From:
Journal of Experimental Hematology
2006;14(3):631-634
- CountryChina
- Language:Chinese
-
Abstract:
B cell activating factor (BAFF) is one of the TNF family member, regulates the survival and maturation of B lymphocyte. BAFF binds to three receptors: BCMA, TACI and BAFF-R. In recent years, studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching, germinal center maintenance, and T cell co-stimulation, that may provide new drugs in the future for the treatment of autoimmune disorders, lymphoma and B cell immunodeficiencies. Therefore, the structure, expression, receptors, biological function and clinical application of BAFF are briefly summarized in this review.
