Role of NK cells in allogeneic hematopoietic stem cell transplantation--review.
- Author:
Xiao-Hong LI
1
;
Chun-Ji GAO
Author Information
1. Department of Hematology, The General Hospital of PLA, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Graft vs Host Disease;
immunology;
Graft vs Leukemia Effect;
immunology;
Hematopoietic Stem Cell Transplantation;
Humans;
Killer Cells, Natural;
immunology;
Transplantation Immunology
- From:
Journal of Experimental Hematology
2006;14(4):845-848
- CountryChina
- Language:Chinese
-
Abstract:
After allogeneic hematopoietic stem cell transplantation (allo-HSCT), the donor cells present a profound immunization therapy efficiency. Among these effector cells, allo-reactivity natural killer (NK) cell activation are concerned with the graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effect. As known, GVHD is primarily a T-cell-mediated event but not initiated by NK cells. NK cells may significantly enhance GVL immune response by using an integration of activating and inhibitory receptors. Allo-reactivity NK cell infusion after allo-HSCT already transits from experiments to clinic. In this review the background on NK cells, and their clinical roles in Allo-HSCT were summarized.
