Evaluation of the expression and significance of Claudin-5 and CD99 in solid-pseudopapillary neoplasms and neuroendocrine tumors of pancreas.
- Author:
Hong-yan ZHENG
1
;
Yan-hong SHI
;
Li-fang ZHANG
;
Ying-zhun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: 12E7 Antigen; Adolescent; Adult; Aged; Antigens, CD; metabolism; Carcinoma, Papillary; metabolism; pathology; Cell Adhesion Molecules; metabolism; Child; Claudin-5; metabolism; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Neuroendocrine Tumors; metabolism; pathology; Pancreatic Neoplasms; metabolism; pathology; Retrospective Studies; Tight Junctions; metabolism; Young Adult
- From: Chinese Journal of Pathology 2013;42(6):372-375
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of endothelium tight junction protein Claudin-5 and intercellular adhesion molecule CD99 in solid-pseudopapillary neoplasms (SPN) and neuroendocrine tumors of pancreas (P-NET), and their significance in the differential diagnoses.
METHODSImmunohistochemical staining of Claudin-5 and CD99 was performed in 37 cases SPN and 21 cases of P-NET.
RESULTSMembranous Claudin-5 expression was observed in all cases of SPN but was absent in all cases of P-NET. The difference was significant (P < 0.01). In SPN, 91.9% (34/37) of the cases displayed paranuclear dot-like immunoreactivity for CD99; in contrast, 61.9% (13/21) of the cases of P-NET displayed membranous staining (P < 0.01). There was a positive association between the expression of Claudin-5 and CD99 in SPN (r = 0.421,P = 0.001).
CONCLUSIONSAlthough the macroscopic and microscopic features of SPN are quite characteristic, they may not allow confident differentiation from P-NET in all cases, especially when these characteristics are not classical. If necessary, immunostaining for Claudin-5 and CD99 can help to differentiate between these entities.
