Invasive lobular carcinoma of basal-like subtype of breast: a clinicopathologic analysis.
- Author:
Li-ying ZHANG
1
;
Lan-xiang GAO
;
Guang LIU
;
Guang-zhi YANG
;
Juan CHENG
;
Hua-ye DING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Biomarkers, Tumor; metabolism; Breast Neoplasms; drug therapy; metabolism; pathology; surgery; Cadherins; metabolism; Carcinoma, Lobular; drug therapy; metabolism; pathology; secondary; surgery; Catenins; metabolism; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Immunohistochemistry; Keratin-5; metabolism; Keratin-6; metabolism; Ki-67 Antigen; metabolism; Liver Neoplasms; secondary; Lymphatic Metastasis; Mastectomy, Modified Radical; Middle Aged; Receptor, Epidermal Growth Factor; metabolism; Receptor, ErbB-2; metabolism; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Thoracic Neoplasms; secondary; Thoracic Wall; Tumor Suppressor Protein p53; metabolism
- From: Chinese Journal of Pathology 2013;42(9):599-603
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathologic features, clinical progress and prognosis of the basal-like subtype of invasive lobular carcinoma (ILC) of the breast.
METHODSFour cases of ILC were analyzed by detailed histopathologic observation and immunohistochemical staining for E-cadherin, p120 catenin, ER, PR, HER2, CK5/6, EGFR, p63, p53, Ki-67 using MaxVision method. The follow-up and clinical data were analyzed.
RESULTSMorphologically, one case was mixed ILC and three cases were pleomorphic ILC. The tumor cells were negative for E-cadherin except one case with focal membrane positivity, and all showed p120 catenin cytoplasmic positivity except one case with focal membrane positivity. All cases were negative for ER, PR and HER2 (triple negative), and positive for EGFR and CK5/6. Two cases were positive for p63. The cases were partly and weakly positive for p53, and the Ki-67 positive rate was between 30% and 75%. Follow-up data showed that two cases developed chest wall metastases, and in one case, there was progression to liver and abdominal metastases.
CONCLUSIONSILC of the breast are ER, PR and HER2 "triple negative", CK5/6 and EGFR positive, indicative of basal-like characteristics. Basal-like subtype of ILC are peculiarly prone to metastasis and poor response to chemotherapy, suggesting that it is associated with poor prognosis.
