Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida.

Abiodun Falodun; Vincent Imieje; Osayewenre Erharuyi; Ahomafor Joy; Peter Langer; Melissa Jacob; Shabanna Khan; Mohammed Abaldry; Mark Hamann

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Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida.

Author: Abiodun FALODUN ^{1
,

2} ; Vincent IMIEJE ³ ; Osayewenre ERHARUYI ³ ; Ahomafor JOY ⁴ ; Peter LANGER ⁵ ; Melissa JACOB ⁶ ; Shabanna KHAN ⁶ ; Mohammed ABALDRY ⁷ ; Mark HAMANN ⁷
Author Information

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria
2. Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38655, USA.
3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria
4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, 300001, Nigeria.
5. Institute of Organic Chemistry, University of Rostock, 18509, Rostock, Germany.
6. National Center for Natural Products Research, Institute of Pharmaceutical Sciences, University of Mississippi, 38677, USA.
7. Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS 38655, USA.
Publication Type:Journal Article
Keywords: Antimalarial; Antimicrobial; Jatropha multifida; Leishmaniasis; Stem bark
From:Asian Pacific Journal of Tropical Biomedicine 2014;4(5):374-378
CountryChina
Language:English
Abstract:
OBJECTIVETo investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine.
METHODSThe methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature.
RESULTSThe three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC50 of 8.2 and 8.7 µg/mL, respectively.
CONCLUSIONSThe research lends support to the ethnomedicinal use of the plant in combating microbial infections, leishmaniasis and malarial infections.