Laterodorsal Tegmentum and Pedunculopontine Tegmental Nucleus Circuits Regulate Renal Functions: Neuroanatomical Evidence in Mice Models
10.1007/s11596-012-0038-2
- Author:
YE DAWEI
1
;
GUO QINGQING
;
FENG JUEPING
;
LIU CHENG
;
YANG HUI
;
GAO FENG
;
ZHOU WAIPING
;
ZHOU LING
;
XIANG HONGBING
;
LI RONGCHUN
Author Information
1. Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
- Keywords:
kidney;
laterodorsal tegmentum nucleus;
pedunculopontine tegmental nucleus;
alpha-herpes virus;
tryptophan hydroxylase (TPH);
tyrosine hydroxylase (TH)
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2012;32(2):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Neurons in the laterodorsal tegmentum (LDTg) and pedunculopontine tegmental nucleus (PPTg) play important roles in central autonomic circuits of the kidney.In this study,we used a combination of retrograde tracers pseudorabies virus (PRV)-614 and fluorescence immunohistochemistry to characterize the neuroanatomic substrate of PPTg and LDTg innervating the kidney in the mouse.PRV-614-infected neurons were retrogradely labeled in the rostral and middle parts of LDTg,and themiddle and caudal parts of PPTg after tracer injection in the kidney.PRV-614/TPH double-labeled neurons were mainly localized in the rostral of LDTg,whereas PRV-614/TH neurons were scattered within the three parts of LDTg.PRV-614/TPH and PRV-614/TH neurons were located predominantly in the caudal of PPTg (cPPTg).These data provided direct neuroanatomical foundation for the identification of serotonergic and catecholaminergic projections from the mid-brain tegmentum to the kidney.
