Diterpene constituents of Tripterygium willfordii (II).
- Author:
Sui LIN
1
;
Hui-Qing QUE
;
Hua-Yi PENG
;
Li-Ping QIAN
;
Shun-Min GUO
;
Yuan-Chao LI
Author Information
1. Fujian Institute of Medical Sciences, Fuzhou 350001, China. linsui_syy@sina.com.cn
- Publication Type:Journal Article
- MeSH:
Cell Proliferation;
drug effects;
Diterpenes;
chemistry;
isolation & purification;
pharmacology;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
HL-60 Cells;
Humans;
K562 Cells;
Molecular Structure;
Plant Roots;
chemistry;
Plants, Medicinal;
chemistry;
Tripterygium;
chemistry;
Triterpenes;
chemistry;
isolation & purification
- From:
Acta Pharmaceutica Sinica
2011;46(8):942-945
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the constituents and pharmacology of Tripterygium plants (Tripterygium willfordii Hook.f), a variety of chromatography methods were used. Four compounds were isolated from Tripterygium plant and their structures were elucidated by UV, IR, MS, HR-MS, 1H NMR, 13C NMR and 2D-NMR techniques. The isolated compounds were named as triptonide (1), neo-triptetraolide (2), 2alpha-hydroxytriptonide (3), and 15-hydroxytriptonide (4), separately. Compounds 3, 4 belong to new diterpenoids, which can inhibit the growth of K562 cells (leukemia cells) and HL60 cells (acute myeloid leukemia cells).
