Advances in functional studies of nonstructural proteins and development of antiviral agents for enterovirus 71.
- Author:
Xian-Yun QIN
1
;
Lin LIN
;
Yan YANG
;
Shu-Xiang ZHANG
;
Jian-Qiang KONG
;
Ke-Di CHENG
;
Yun-Feng ZHAO
;
Wei WANG
Author Information
1. College of Life Science, Qufu Normal University, Qufu 273165, China.
- Publication Type:Journal Article
- MeSH:
Antiviral Agents;
pharmacology;
Enterovirus A, Human;
enzymology;
genetics;
isolation & purification;
Hand, Foot and Mouth Disease;
drug therapy;
virology;
Humans;
Molecular Targeted Therapy;
Peptide Hydrolases;
chemistry;
metabolism;
physiology;
Protein Kinase Inhibitors;
pharmacology;
RNA, Viral;
genetics;
Viral Nonstructural Proteins;
chemistry;
metabolism;
physiology;
Virus Replication;
drug effects
- From:
Acta Pharmaceutica Sinica
2011;46(7):753-761
- CountryChina
- Language:Chinese
-
Abstract:
Human enterovirus 71 (EV71) is one of the major etiological agents for the hand, foot, and month disease (HFMD) and is causing frequent, widespread occurrence in the mainland of China. The single positive-stranded RNA genome of EV71 is translated into a single polyprotein which is autocleavaged into structural and nonstructural proteins. The functions of many nonstructural proteins characterized in the life cycle of virus are potential targets for blocking viral replication. This article reviews the studies of the structures and functions of nonstructural proteins of EV71 and the anti-enterovirus 71 drugs targeting on these nonstructural proteins.
