Simultaneous determination of fumonisins B1 and B2 in traditional Chinese medicines by high-performance liquid chromatography-tandem mass spectrometry.
- Author:
Ting-Ting XIE
1
;
Feng QIU
;
Mei-Hua YANG
;
Ai-Di QI
Author Information
1. Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China.
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
Drug Contamination;
Drugs, Chinese Herbal;
chemistry;
Fumonisins;
analysis;
Medicine, Chinese Traditional;
Plants, Medicinal;
chemistry;
Tandem Mass Spectrometry
- From:
Acta Pharmaceutica Sinica
2011;46(7):822-827
- CountryChina
- Language:Chinese
-
Abstract:
A rapid and sensitive analytical method was developed for the simultaneous determination of fumonisins B1 and B2 in traditional Chinese medicines by HPLC-MS/MS. The detection limits for fumonisins B1 and B2 were 0.25 ng x mL(-1) corresponding to 2 microg x kg(-1) in samples. Recoveries from different samples spiked with fumonisins B1 and B2 at levels ranging from 0.2 to 3 mg x kg(-1) were 84.0%-96.1% and 86.3%-99.3%, respectively. Among the total of 34 samples purchased from local markets, ten samples of which were visibly moldy samples due to inappropriate storage, and 24 were normal samples. The results showed that 6 of the visibly moldy samples and 5 of the normal samples were contaminated with total fumonisins at levels ranging 82.4-2349 microg x kg(-1) and 102-729 microg x kg(-1), respectively.
